Name of the Intermediate  CAS No.

 

1) Abacavir Sulphate Intermediate:

 

(1S,4R)-4-[(2-Amino-6-Chloro-5-Formamido-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanolc 

 

  [171887-04-0]

 

2) Emtricitabine Intermediate:

 

(2R-5S)-5-(4-Amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-{1,3}-oxathiolane-2-carboxylic acid, 2S-Isopropyl-5R-methyl-1R-cyclohexyl ester 

 

  [764659-72-5]

 

3) Lamivudine Intermediate:

 

4-Amino-2-oxo-pyrimidinyl-oxathiolane-2- carboxylic acid-isopropyl-methyl Cyclohexyl ester 

 

  [147126-73-6]

 

4) Nebivolol HCl Intermediate:

 

6-Fluoro-3,4-dihydro-2H-1-benzopryan-2-carboxylic acid

 

4-(5-Fluoro-2-hydroxyphenyl)-4-oxo-2-butenoic acid

6-Fluoro-4-oxo-chromane-2-carboxylic acid  )

 

6-Fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid

 

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

(Mixture of two diasteromers)  

 

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopryan-2-carboxylic acid 

 

(R)- 6-Fluoro-3,4-dihydro-2H-1-benzopryan-2-carboxylic acid 

 

 
  [ 99199-60-7] 
  [118803-65-9]
  [ 99199-59-4 ]
  [ 99199-90-3 ] 
  [129101-36-6]
  [129101-37-7]

 

5) Fluconazole Intermediate:

 

2,4-difluoro-2-(1H-1,2,4-triazole-1yl)acetophenone  

 

 (OR)

 

1-(2,4-Difluoro phenyl)-2-(1H-1,2,4-Triazole-1-yl) Ethanone  

 

  [ 86404-63-9]
 

 

            Products under Development/Scale Up
Name of the Intermediate CAS No.

 

1) Pregabalin:

 

3- Aminomethyl-5-methyl heanoic acid (Racemic Pregabalin)

 

 

 

2) Canagliflozin Intermediates:

 

2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 

2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 

 

  [1030825-21-8]

 

3) Dapagliflozin Intermediates:

 

4-(5-bromo-2-chlorobenzyl)phenol 

4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene   

 

  [864070-18-8]

  [461432-23-5]

 

4) Empagliflozin Intermediates:

 

(R)-3-(4-(5-bromo-2-chlorobenzyl)phenix)tetrahydrofuran 

2-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2methoxytetrahydro-2H-pyran-3,4,5-triol

 

  [915095-90-8]

 

  [915095-95-3]

 

5) Macitentan:

 

5-(4-Bromophenyl)-4,6-dichloropyrimidine

5-Bromo-2-chloropyrimidine 

 

  [146533-41-7]

 

  [32779-36-5]

 

 

6) Tamsulosin HCl:

 

2-(2-Ethoxy phenoxy) ethyl bromide

(R)-(+)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide Hydrochloride 

 

  [4463-59-6] 

  [112101-75-4 ]

 

7) Apremilast:

 

1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethylamine

[(RS)-Aminosulfone derivative]

3-Acetylaminophthalic anhydride

 

  [253168-94-4]

 

  [6296-53-3]

 

8) Tetrabenazine:

 

3-((Dimethylamino)(Methyl)-5-methylhexan02-One.methyliodide

 

  [1069-62-1]

 

9) Sacubitril:

 

(2R,4S)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpentanoic acid 

(2R,4S)-ethyl 4-amino-5-(biphenyl-4-yl)-2-methylpentanoate hydrochloride

 

  [1012341-50-2]

 

  [149690-12-0]

 

10) Ibrutinib:

 

3 Iodo-1H Pyrazole[ 3,4,d) Pyridine 4 amine

 

 [151266-23-8]